Aim: The aim of this study was to investigate the utility of serological tests for the diagnosis of COVID-19 during the first week of symptom onset in patients confirmed with the real-time RT-PCR. Materials & methods: A systematic review and meta-analysis of 58 publications were performed using data obtained from Academic Search Ultimate, Africa-wide, Scopus, Web of Science and MEDLINE. Results: We found that the highest pooled sensitivities were obtained with ELISA IgM-IgG and chemiluminescence immunoassay IgM tests. Conclusion: Serological tests have low sensitivity within the first week of symptom onset and cannot replace nucleic acid amplification tests. However, serological assays can be used to support nucleic acid amplification tests.
【저자키워드】 COVID-19, serology, RT-PCR, laboratory diagnosis, 【초록키워드】 Meta-analysis, serological test, systematic review, ELISA, sensitivity, Serological assay, Patient, real-time RT-PCR, nucleic acid amplification, utility, chemiluminescence, Support, symptom onset, Web of Science, material, highest, performed, can be used, diagnosis of COVID-19, 【제목키워드】 Meta-analysis, systematic review, sensitivity, Antibody test, laboratory confirmation,