The rapid spread, severity, and lack of specific treatment for COVID-19 resulted in hasty drug repurposing. Conceptually, trials of antivirals were well-accepted, but twentieth century antimalarials sparked an impassioned global debate. Notwithstanding, antiviral and immunomodulatory effects of aminoquinolines have been investigated in vitro, in vivo and in clinical trials for more than 30 years. We review the mechanisms of action of (hydroxy)chloroquine on immune cells and networks and discuss promises and pitfalls in the fight against SARS-CoV-2, the agent of the COVID-19 outbreak.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, Chloroquine, Hydroxychloroquine, immune modulation, 【초록키워드】 clinical trial, Trial, Antiviral, severity, in vitro, antimalarial, Spread, COVID-19 outbreak, in vivo, mechanism, Immune cell, specific treatment, immunomodulatory effect, lack, investigated, 【제목키워드】 option, aminoquinoline, the SARS-CoV-2,
【저자키워드】 COVID-19, SARS-CoV-2, Chloroquine, Hydroxychloroquine, immune modulation, 【초록키워드】 clinical trial, Trial, Antiviral, severity, in vitro, antimalarial, Spread, COVID-19 outbreak, in vivo, mechanism, Immune cell, specific treatment, immunomodulatory effect, lack, investigated, 【제목키워드】 option, aminoquinoline, the SARS-CoV-2,