After the outburst of the SARS-CoV-2 pandemic, a worldwide research effort has led to the uncovering of many aspects of the COVID-19, among which we can count the outstanding role played by inflammatory cytokine milieu in the disease progression. Despite that, molecular mechanisms that regulate SARS-CoV-2 pathogenesis are still almost unidentified. In this study, we investigated whether the pro-inflammatory milieu of the host affects the susceptibility of SARS-CoV-2 infection by modulating ACE2 and TMPRSS2 expression. Our results indicated that the host inflammatory milieu favors SARS-CoV-2 infection by directly increasing TMPRSS2 expression. We unveiled the molecular mechanism that regulates this process and that can be therapeutically advantageously targeted.
【저자키워드】 SARS-CoV-2, p38, GATA2, IL1β, TMPRSS2, 【초록키워드】 COVID-19, ACE2, pandemic, SARS-COV-2 infection, susceptibility, progression, molecular mechanism, Research, SARS-CoV-2 pathogenesis, Inflammatory cytokine, Inflammatory, regulate, favor, TMPRSS2 expression, effort, pro-inflammatory, Host, Affect, indicated, investigated, the disease, modulating, the SARS-CoV-2, 【제목키워드】 IL1β, axis,