A new coronavirus respiratory disease (COVID-19) caused by the SARS-CoV-2 virus, surprised the entire world, producing social, economic, and health problems. The COVID-19 triggers a lung infection with a multiple proinflammatory cytokine storm in severe patients. Without effective and safe treatments, COVID-19 has killed thousands of people, becoming a pandemic. Stem cells have been suggested as a therapy for lung-related diseases. In particular, mesenchymal stem cells (MSCs) have been successfully tested in some clinical trials in patients with COVID-19. The encouraging results positioned MSCs as a possible cell therapy for COVID-19. The amniotic membrane from the human placenta at term is a valuable stem cell source, including human amniotic epithelial cells (hAECs) and human mesenchymal stromal cells (hAMSCs). Interestingly, amnion cells have immunoregulatory, regenerative, and anti-inflammatory properties. Moreover, hAECs and hAMSCs have been used both in preclinical studies and in clinical trials against respiratory diseases. They have reduced the inflammatory response and restored the pulmonary tissue architecture in lung injury in vivo models. Here, we review the existing data about the stem cells use for COVID-19 treatment, including the ongoing clinical trials. We also consider the non-cellular therapies that are being applied. Finally, we discuss the human amniotic membrane cells use in patients who suffer from immune/inflammatory lung diseases and hypothesize their possible use as a successful treatment against COVID-19.
【저자키워드】 COVID-19, stem cells, SARS-CoV-2, Mesenchymal stem cells, Stem cell therapy, Amnion, Human amniotic epithelial cells, Human amniotic mesenchymal stromal cells, 【초록키워드】 Treatment, stem cells, coronavirus, clinical trial, pandemic, therapy, Diseases, Cell therapy, Placenta, clinical trials, Lung disease, SARS-CoV-2 virus, Lung infection, Mesenchymal stem cells, MSCs, cytokine, Lung injury, respiratory diseases, COVID-19 treatment, Health, Lung diseases, Respiratory disease, Patient, membrane, epithelial cells, respiratory, regenerative, preclinical study, New coronavirus, in vivo models, Inflammatory response, MSC, Trigger, Safe, epithelial cell, stem cell, triggers, in some, preclinical studies, stromal cells, stromal cell, Proinflammatory cytokine, severe patients, tissue, problems, anti-inflammatory properties, term, hAEC, effective, Cell, tested, caused, applied, reduced, suggested, producing, restored, amniotic, patients with COVID-19, positioned, the SARS-CoV-2 virus, therapy for COVID-19, 【제목키워드】 stem cells, therapy, Cell, amniotic, the SARS-CoV-2,