The global expansion of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as one of the greatest public health challenges and imposes a great threat to human health. Innate immunity plays vital roles in eliminating viruses through initiating type I interferons (IFNs)-dependent antiviral responses and inducing inflammation. Therefore, optimal activation of innate immunity and balanced type I IFN responses and inflammation are beneficial for efficient elimination of invading viruses. However, SARS-CoV-2 manipulates the host’s innate immune system by multiple mechanisms, leading to aberrant type I IFN responses and excessive inflammation. In this review, we will emphasize the recent advances in the understanding of the crosstalk between host innate immunity and SARS-CoV-2 to explain the imbalance between inflammation and type I IFN responses caused by viral infection, and explore potential therapeutic targets for COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, Inflammation, Innate immunity, type I interferons, 【초록키워드】 coronavirus disease, viruses, public health, viral infection, coronavirus, Immunity, virus, type I interferon, innate immune system, Health, response, mechanisms, antiviral response, Innate, host innate immunity, Type I IFN, acute respiratory syndrome, Activation, excessive inflammation, potential therapeutic target, caused, explain, eliminating, vital role, 【제목키워드】 response, IFN, Imbalance, Type,