Since its emergence at the end of 2019, SARS-CoV-2 has spread worldwide at a very rapid pace. While most infected individuals have an asymptomatic or mild disease, a minority, mainly the elderly, develop a severe disease that may lead to a fatal acute respiratory distress syndrome (ARDS). ARDS results from a highly inflammatory immunopathology process that includes systemic manifestations and massive alveolar damages that impair gas exchange. The present review summarizes our current knowledge in the rapidly evolving field of SARS-CoV-2 immunopathology, emphasizing the role of specific T cell responses. Indeed, accumulating evidence suggest that while T-cell response directed against SARS-CoV-2 likely plays a crucial role in virus clearance, it may also participate in the immunopathology process that leads to ARDS.
【저자키워드】 SARS-CoV-2, immunopathology, Complement activation, T cell response, B cell response, 【초록키워드】 ARDS, knowledge, T-cell Response, Spread, Asymptomatic, T cell responses, Gas exchange, Mild, disease, acute respiratory distress, Evidence, Inflammatory, severe disease, virus clearance, infected individual, syndrome, while, develop, include, impair, accumulating, massive alveolar damage, systemic manifestation, 【제목키워드】 lesson,