Since the onset of the COVID-19 pandemic in the fall of 2019 over 4 million people have been infected and over 280,000 have died ( 1 ). Information about the SARS-CoV2 virus is evolving rapidly. At this time there are no interventions proven to be effective for cases infected with SARS-CoV2. Current knowledge about the clinical and laboratory manifestations of COVID-19 infection is reviewed and combined with knowledge about the immunopathogenic mechanisms of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV1) and Middle East Respiratory Syndrome (MERS) to formulate theories and suggest possible therapeutic interventions. SARS-CoV2 immunopathogenic mechanisms vary from immunosuppression that initially enables viral escape to a hyperinflammatory immune response. Ultimately therapeutic intervention will be phase dependent.
【저자키워드】 COVID-19, immunology, Immunosuppression, Intervention, hyperinflammation, 【초록키워드】 SARS-CoV2, immune response, knowledge, COVID-19 pandemic, MERS, virus, Laboratory, COVID-19 infection, respiratory, mechanism, manifestation, Middle East, viral escape, therapeutic interventions, therapeutic intervention, Hyperinflammatory, effective, current, died,