The coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has been declared as a worldwide public health emergency. Interestingly, severe COVID-19 is characterized by fever, hyperferritinemia, and a hyper-inflammatory process with a massive release of pro-inflammatory cytokines, which may be responsible for the high rate of mortality. These findings may advocate for a similarity between severe COVID-19 and some challenging rheumatic diseases, such as adult onset Still’s disease, secondary hemophagocytic lymphohistiocytosis, and catastrophic anti-phospholipid syndrome, which have been included in the “hyperferritinemic syndrome” category. Furthermore, as performed in these hyper-inflammatory states, severe COVID-19 may benefit from immunomodulatory therapies.
【저자키워드】 COVID-19, hyper-inflammation, Hyperferritinemia, haemophagocytic lymphohistiocytosis, hyperferritinaemic syndrome, adult onset Still's disease, catastrophic anti-phospholipid syndrome, 【초록키워드】 coronavirus disease, SARS-CoV-2, Rheumatic diseases, Mortality, severe COVID-19, Fever, pro-inflammatory cytokines, public health emergency, secondary hemophagocytic lymphohistiocytosis, disease, similarity, acute respiratory disease, Immunomodulatory therapies, syndrome, benefit, catastrophic, responsible, performed, caused, characterized, Still, 【제목키워드】 piece, puzzle, storm,