The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have been reported in association with COVID-19, but the nature of the impairments was not specified. Here, we report a case of a female patient diagnosed with glaucoma on re-hospitalization for ocular complications two months after being discharged from the hospital upon recovery from COVID-19. Meanwhile, the patient was found re-positive for SARS-CoV-2 in the upper respiratory tract. The infection was also diagnosed in the aqueous humor through immunostaining with antibodies against the N protein and S protein of SARS-CoV-2. Considering the eye is an immune-privileged site, we speculate that SARS-CoV-2 survived in the eye and resulted in the patient testing re-positive for SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, Aqueous humor, immunostaining, Glaucoma, 【초록키워드】 coronavirus disease, coronavirus, pandemic, S protein, antibody, hospital, Infection, clinical manifestations, female, Patient, Complication, upper respiratory tract, association, acute respiratory syndrome, impairment, abnormality, ocular, caused, reported, the patient, diagnosed, discharged, survived, the N protein, with COVID-19,