COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory distress syndrome (ARDS) in about 15 % of the cases. Mortality in COVID-19 patients has been linked to the presence of the so-called “cytokine storm” induced by the virus. Excessive production of proinflammatory cytokines leads to ARDS aggravation and widespread tissue damage resulting in multi-organ failure and death. Targeting cytokines during the management of COVID-19 patients could improve survival rates and reduce mortality.
All Keywords
【저자키워드】 COVID-19, ARDS, IL-6, cytokine, storm, 【초록키워드】 pandemic, Pneumonia, droplet, virus, management, death, respiratory tract, survival rate, acute respiratory distress, Contact, COVID-19 patient, Proinflammatory cytokine, tissue damage, syndrome, multi-organ failure, targeting, infect, widespread, reduce mortality, IMPROVE, resulting, transmitted, the WHO, “cytokine storm”,
【저자키워드】 COVID-19, ARDS, IL-6, cytokine, storm, 【초록키워드】 pandemic, Pneumonia, droplet, virus, management, death, respiratory tract, survival rate, acute respiratory distress, Contact, COVID-19 patient, Proinflammatory cytokine, tissue damage, syndrome, multi-organ failure, targeting, infect, widespread, reduce mortality, IMPROVE, resulting, transmitted, the WHO, “cytokine storm”,