Neurological disorders caused by neuroviral infections are an obvious pathogenic manifestation. However, non-neurotropic viruses or peripheral viral infections pose a considerable challenge as their neuropathological manifestations do not emerge because of primary infection. Their secondary or bystander pathologies develop much later, like a syndrome, during and after the recovery of patients from the primary disease. Massive inflammation caused by peripheral viral infections can trigger multiple neurological anomalies. These neurological damages may range from a general cognitive and motor dysfunction up to a wide spectrum of CNS anomalies, such as Acute Necrotizing Hemorrhagic Encephalopathy, Guillain-Barré syndrome, Encephalitis, Meningitis, anxiety, and other audio-visual disabilities. Peripheral viruses like Measles virus, Enteroviruses, Influenza viruses (HIN1 series), SARS-CoV-1, MERS-CoV, and, recently, SARS-CoV-2 are reported to cause various neurological manifestations in patients and are proven to be neuropathogenic even in cellular and animal model systems. This review presents a comprehensive picture of CNS susceptibilities toward these peripheral viral infections and explains some common underlying themes of their neuropathology in the human brain.
【저자키워드】 SARS-CoV-2, Coronaviruses, Cytokine storm, Influenza, Encephalitis, Neuroinflammation, microglial priming, 【초록키워드】 Inflammation, pathology, viral infection, Anxiety, susceptibility, Infection, animal model, virus, SARS-CoV-1, MERS-CoV, Brain, Patient, disease, CNS, Primary infection, cellular, measles virus, neurological, manifestation, dysfunction, cognitive, bystander, syndrome, anomalies, pathogenic, disorder, massive, neurological manifestation, peripheral, develop, caused, reported, explain, 【제목키워드】 damage, catastrophe,