In the era of COVID-19, understanding how our immune system responds to viral infections is more pertinent than ever. Immunodeficiencies with very low or absent B cells offer a valuable model to study the role of humoral immunity against these types of infection. This review looks at the available evidence on viral infections in patients with B cell alymphocytosis, in particular those with X-linked agammaglobulinemia (XLA), Good’s syndrome, post monoclonal-antibody therapy and certain patients with Common Variable Immune Deficiency (CVID). Viral infections are not as infrequent as previously thought in these conditions and individuals with very low circulating B cells seem to be predisposed to an adverse outcome. Particularly in the case of SARS-CoV2 infection, mounting evidence suggests that peripheral B cell alymphocytosis is linked to a poor prognosis.
【저자키워드】 immunodeficiency, B cells, viral infections, Alymphocytosis, immune deficiency, humoral immunity, immune responses, 【초록키워드】 COVID-19, viral infection, therapy, Infection, immune system, SARS-CoV2 infection, adverse outcome, B cell, Humoral immunity, Patient, CVID, Evidence, X-linked agammaglobulinemia, XLA, individual, syndrome, poor prognosis, circulating, offer, variable, common, thought, condition, respond, 【제목키워드】 paradigm, peripheral,