Development of adaptive immunity after COVID-19 and after vaccination against SARS-CoV-2 is predicated on recognition of viral peptides, presented on HLA class II molecules, by CD4+ T-cells. We capitalised on extensive high-resolution HLA data on twenty five human race/ethnic populations to investigate the role of HLA polymorphism on SARS-CoV-2 immunogenicity at the population and individual level. Within populations, we identify wide inter-individual variability in predicted peptide presentation from structural, non-structural and accessory SARS-CoV-2 proteins, according to individual HLA genotype. However, we find similar potential for anti-SARS-CoV-2 cellular immunity at the population level suggesting that HLA polymorphism is unlikely to account for observed disparities in clinical outcomes after COVID-19 among different race/ethnic groups. Our findings provide important insight on the potential role of HLA polymorphism on development of protective immunity after SARS-CoV-2 infection and after vaccination and a firm basis for further experimental studies in this field.
【저자키워드】 COVID-19, SARS-CoV-2, T-cells, cellular immunity, Human Leukocyte Antigens, 【초록키워드】 vaccination, adaptive, Immunity, SARS-COV-2 infection, polymorphism, peptide, anti-SARS-CoV-2, Population, Clinical outcome, protective immunity, Genotype, HLA, development, SARS-CoV-2 proteins, HLA class II, CD4+ T-cells, High-resolution, viral peptides, Variability, population level, individual level, populations, FIVE, predicted, identify, unlikely, groups, inter-individual, 【제목키워드】 Population, HLA, individual, class, Level, influence, Against,