SARS-CoV-2 infection is a new threat to global public health in the 21 st century (2020), which has now rapidly spread around the globe causing severe pneumonia often linked to Acute Respiratory Distress Syndrome (ARDS) and hyperinflammatory syndrome. SARS-CoV-2 is highly contagious through saliva droplets. The structural analysis suggests that the virus enters human cells through the ligation of the spike protein to angiotensin-converting enzyme 2 (ACE 2 ). The progression of Covid-19 has been divided into three main stages: stage I—viral response, stage II—pulmonary phase, and stage III—hyperinflammation phase. Once the patients enter stage III, it will likely need ventilation and it becomes difficult to manage. Thus, it will be of paramount importance to find therapies to prevent or slow down the progression of the disease toward stage III. The key event leading to hyperinflammation seems to be the activation of Th-17 immunity response and Cytokine storm. B 2 -adrenergic receptors (B 2 ARs) are expressed on airways and on all the immune cells such as macrophages, dendritic cells, B and T lymphocytes. Blocking (B 2 AR) has been proven, also in clinical settings, to reduce Th-17 response and negatively modulate inflammatory cytokines including IL-6 while increasing IFN γ . Non-selective beta-blockers are currently used to treat several diseases and have been proven to reduce stress-induced inflammation and reduce anxiety. For these reasons, we speculate that targeting B 2 AR in the early phase of Covid-19 might be beneficial to prevent hyperinflammation.
【저자키워드】 COVID-19, Cytokine storm, SARS-CoV2, immune response, hyperinflammation, Beta adrenergic receptors, beta-blockers, 【초록키워드】 SARS-CoV-2, Inflammation, Saliva, ARDS, therapy, Anxiety, macrophages, Immunity, IL-6, SARS-COV-2 infection, Ventilation, progression, droplets, virus, angiotensin-converting enzyme 2, dendritic cells, airway, Spread, Hyperinflammatory syndrome, IFN, T lymphocytes, receptor, severe pneumonia, respiratory, disease, Inflammatory cytokine, ACE, Immune cell, Structural analysis, Activation, global public health, early phase, clinical settings, treat, contagious, human cell, blocking, stage III, Prevent, globe, the patient, the disease, the spike protein, expressed, modulate, reduce, ARs, 【제목키워드】 SARS-CoV-2, target, combat, New, Can,