The adaptive immune response to severe acute respiratory coronavirus 2 (SARS-CoV-2) is important for vaccine development and in the recovery from coronavirus disease 2019 (COVID-19). Men and cancer patients have been reported to be at higher risks of contracting the virus and developing the more severe forms of COVID-19. Prostate cancer (PCa) may be associated with both of these risks. We show that CD4 + T cells of SARS-CoV-2-unexposed patients with hormone-refractory (HR) metastatic PCa had decreased CD4 + T cell immune responses to antigens from SARS-CoV-2 spike glycoprotein but not from the spiked glycoprotein of the ‘common cold’-associated human coronavirus 229E (HCoV-229E) as compared with healthy male volunteers who responded comparably to both HCoV-229E- and SARS-CoV-2-derived antigens. Moreover, the HCoV-229E spike glycoprotein antigen-elicited CD4 + T cell immune responses cross-reacted with the SARS-CoV-2 spiked glycoprotein antigens. PCa patients may have impaired responses to the vaccination, and the cross-reactivity can mediate antibody-dependent enhancement (ADE) of COVID-19. These findings highlight the potential for increased vulnerability of PCa patients to COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, spike glycoprotein, HCoV-229E, Prostate cancer, 【초록키워드】 coronavirus disease, Vaccine development, immune response, vaccination, Antibody-dependent enhancement, Cancer, CD4, Antigen, cross-reactivity, T cell, SARS-CoV-2 spike glycoprotein, response, male, Patient, antigens, glycoprotein, Adaptive immune response, ADE, cancer patient, higher risk, human coronavirus 229E, Volunteer, Respiratory Coronavirus, contracting the virus, highlight, healthy, reported, form, the SARS-CoV-2, 【제목키워드】 spike, CD4, response, Decreased,