The irruption of SARS-CoV-2 during 2020 has been of pandemic proportions due to its rapid spread and virulence. COVID-19 patients experience respiratory, digestive and neurological symptoms. Distinctive symptom as anosmia, suggests a potential neurotropism of this virus. Amongst the several pathways of entry to the nervous system, we propose an alternative pathway from the infection of the gut, involving Toll-like receptor 4 (TLR4), zonulin, protease-activated receptor 2 (PAR2) and zonulin brain receptor. Possible use of zonulin antagonists could be investigated to attenuate neurological manifestations caused by SARS-CoV-19 infection.
All Keywords
【저자키워드】 SARS-CoV-2, blood-brain barrier, Neurological symptoms, zonulin, gastrointestinal symptoms, tight junctions, Toll-like receptor4, haematogenous route, 【초록키워드】 pandemic, TLR4, Infection, Symptom, virus, Brain, Anosmia, Spread, pathway, nervous system, receptor, virulence, Alternative pathway, COVID-19 patient, Gut, antagonist, neurological manifestation, caused, proportion, investigated, digestive, attenuate,
【저자키워드】 SARS-CoV-2, blood-brain barrier, Neurological symptoms, zonulin, gastrointestinal symptoms, tight junctions, Toll-like receptor4, haematogenous route, 【초록키워드】 pandemic, TLR4, Infection, Symptom, virus, Brain, Anosmia, Spread, pathway, nervous system, receptor, virulence, Alternative pathway, COVID-19 patient, Gut, antagonist, neurological manifestation, caused, proportion, investigated, digestive, attenuate,