Immune dysfunction and aberrant cytokine storms often lead to rapid exacerbation of the disease during late infection stages in SARS-CoV and MERS-CoV patients. However, the underlying immunopathology mechanisms are not fully understood, and there has been little progress in research regarding the development of vaccines, anti-viral drugs, and immunotherapy. The newly discovered SARS-CoV-2 (2019-nCoV) is responsible for the third coronavirus pandemic in the human population, and this virus exhibits enhanced pathogenicity and transmissibility. SARS-CoV-2 is highly genetically homologous to SARS-CoV, and infection may result in a similar clinical disease (COVID-19). In this review, we provide detailed knowledge of the pathogenesis and immunological characteristics of SARS and MERS, and we present recent findings regarding the clinical features and potential immunopathogenesis of COVID-19. Host immunological characteristics of these three infections are summarised and compared. We aim to provide insights and scientific evidence regarding the pathogenesis of COVID-19 and therapeutic strategies targeting this disease.
【저자키워드】 immunology, SARS-CoV-2, SARS-CoV, MERS-CoV, Novel coronavirus, 【초록키워드】 COVID-19, Cytokine storm, coronavirus, pandemic, Pathogenesis, Vaccines, knowledge, Immunotherapy, 2019-nCoV, Infection, immunopathology, MERS, virus, Transmissibility, Immunopathogenesis, Research, pathogenicity, homologous, disease, patients, clinical feature, mechanism, therapeutic strategy, Evidence, Anti-viral drugs, dysfunction, Stage, pathogenesis of COVID-19, clinical disease, immunological characteristics, responsible, the disease, exhibit, recent finding, 【제목키워드】 Comparative,