The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing major threat to global health and has posed significant challenges for the treatment of severely ill COVID-19 patients. Several studies have reported that cytokine storms are an important cause of disease deterioration and death in COVID-19 patients. Consequently, it is important to understand the specific pathophysiological processes underlying how cytokine storms promote the deterioration of COVID-19. Here, we outline the pathophysiological processes through which cytokine storms contribute to the deterioration of SARS-CoV-2 infection and describe the interaction between SARS-CoV-2 and the immune system, as well as the pathophysiology of immune response dysfunction that leads to acute respiratory distress syndrome (ARDS), multi-organ dysfunction syndrome (MODS), and coagulation impairment. Treatments based on inhibiting cytokine storm-induced deterioration and occurrence are also described.
【저자키워드】 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronavirus disease 2019 (COVID-19), acute respiratory distress syndrome (ARDS), Cytokine storms, multi-organ dysfunction syndrome (MODS), 【초록키워드】 COVID-19, Treatment, coronavirus disease, SARS-CoV-2, ARDS, Cytokine storm, coronavirus, immune response, pandemic, multi-organ dysfunction, SARS-COV-2 infection, cytokine, immune system, Deterioration, Health, pathophysiology, patients, COVID-19 patients, acute respiratory distress, Interaction, dysfunction, acute respiratory syndrome, syndrome, MODS, Occurrence, described, caused, reported, contribute, promote, inhibiting, coagulation impairment, death in COVID-19, disease deterioration, pathophysiological, 【제목키워드】 COVID-19, determinant,