Objective: Review and integrate the neurologic manifestations of the Coronavirus Disease 2019 (COVID-19) pandemic, to aid medical practitioners who are combating the newly derived infectious disease. Methods: We reviewed the clinical research, consisting of mainly case series, on reported neurologic manifestations of COVID-19. We also reviewed basic studies to understand the mechanism of these neurologic symptoms and signs. Results: We included 79 studies for qualitative synthesis and 63 studies for meta-analysis. The reported neurologic manifestations were olfactory/taste disorders (35.6%), myalgia (18.5%), headache (10.7%), acute cerebral vascular disease (8.1%), dizziness (7.9%), altered mental status (7.8%), seizure (1.5%), encephalitis, neuralgia, ataxia, Guillain-Barre syndrome, Miller Fisher syndrome, intracerebral hemorrhage, polyneuritis cranialis, and dystonic posture. Conclusions: Neurologic manifestations in COVID-19 may alert physicians and medical practitioners to rule in high-risk patients. The increasing incidence of olfactory/taste disorders, myalgia, headache, and acute cerebral vascular disease renders a possibility that COVID-19 could attack the nervous system. The cytokine secretion and bloodstream circulation (viremia) are among the most possible routes into the nervous system.
【저자키워드】 COVID-19, ACE2, pandemic, cytokine, headache, Taste, olfactory, neurologic, 【초록키워드】 Meta-analysis, review, Symptom, Infectious disease, Encephalitis, Case series, Viremia, Research, Miller fisher syndrome, nervous system, circulation, incidence, mechanism, High-risk patients, Guillain-barrè syndrome, Intracerebral hemorrhage, Seizure, Altered mental status, manifestation, Dizziness, myalgia, Ataxia, disorders, bloodstream, disorder, physician, cytokine secretion, Practitioner, combating, reported, cerebral vascular disease, cranialis, 【제목키워드】 review, manifestation, systemic,