SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most prominent symptoms of SARS-CoV-2 infection are respiratory. However, accumulating evidence highlights involvement of the central nervous system (CNS). This includes headache, anosmia, meningoencephalitis, acute ischemic stroke, and several presumably post/para-infectious syndromes and altered mental status not explained by respiratory etiologies. Interestingly, previous studies in animal models emphasized the neurotropism of coronaviruses; thus, these CNS manifestations of COVID-19 are not surprising. This minireview scans the literature regarding the involvement of the CNS in coronavirus infections in general, and in regard to the recent SARS-CoV-2, specifically.
【저자키워드】 COVID-19, SARS-CoV-2, coronaviral infections, neurological & psychiatric symptoms, brain disorders, neurological infection and inflammation, 【초록키워드】 Coronavirus infection, Corona virus, coronavirus, stroke, SARS-COV-2 infection, animal model, Symptom, headache, virus, Anosmia, Spread, morbidity and mortality, Central nervous system, disease, CNS, Evidence, Altered mental status, manifestation, worldwide pandemic, syndrome, previous study, highly pathogenic, etiologies, highlight, Wuhan, China, caused, include, explained, accumulating, 【제목키워드】 manifestation, System, nervous,