Coronavirus Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2), began in December 2019, in Wuhan, China and was promptly declared as a pandemic by the World Health Organization (WHO). As an acute respiratory disease, COVID-19 uses the angiotensin-converting enzyme 2 (ACE2) receptor, which is the same receptor used by its predecessor, SARS-CoV, to enter and spread through the respiratory tract. Common symptoms of COVID-19 include fever, cough, fatigue and in a small population of patients, SARS-CoV-2 can cause several neurological symptoms. Neurological malaise may include severe manifestations, such as acute cerebrovascular disease and meningitis/encephalitis. Although there is evidence showing that coronaviruses can invade the central nervous system (CNS), studies are needed to address the invasion of SARS-CoV-2 in the CNS and to decipher the underlying neurotropic mechanisms used by SARS-CoV-2. This review summarizes current reports on the neurological manifestations of COVID-19 and addresses potential routes used by SARS-CoV-2 to invade the CNS.
【저자키워드】 COVID-19, SARS-CoV-2, Inflammation, Cytokines, Neurological complications, 【초록키워드】 ACE2, pandemic, fatigue, SARS-CoV, cough, angiotensin-converting enzyme 2, Spread, Fever, Manifestations, WHO, Central nervous system, Neurological symptoms, respiratory tract, receptor, respiratory, CNS, patients, mechanism, Coronavirus-2, Evidence, Invasion, acute respiratory disease, World Health Organization, malaise, symptoms of COVID-19, acute cerebrovascular disease, neurological manifestation, neurotropic, common, Wuhan, China, caused, include, coronavirus, 【제목키워드】 coronavirus 2, Impact, respiratory, nervous,