We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with the vaccination, the immune-related nature of the disease as well as the lack of other canonical precipitating factors suggested that AHEM was a vaccine-related adverse effect. We believe that AHEM might reflect a novel COVID-19 vaccine-related adverse event for which physicians should be vigilant and sensitized.
All Keywords
【저자키워드】 COVID-19, vaccination, ChAdOx1 nCoV-19, Acute disseminated encephalomyelitis, acute hemorrhagic encephalomyelitis, acute hemorrhagic leukoencephalitis, Weston-Hurst syndrome, 【초록키워드】 magnetic resonance imaging, variant, Brain, adverse event, cerebrospinal fluid, association, Analysis, Diagnostic Criteria, adverse effect, Hemorrhagic, Factor, physician, lack, diagnosed, the disease, suggested, canonical, 【제목키워드】 SARS-CoV-2, Encephalomyelitis,
【저자키워드】 COVID-19, vaccination, ChAdOx1 nCoV-19, Acute disseminated encephalomyelitis, acute hemorrhagic encephalomyelitis, acute hemorrhagic leukoencephalitis, Weston-Hurst syndrome, 【초록키워드】 magnetic resonance imaging, variant, Brain, adverse event, cerebrospinal fluid, association, Analysis, Diagnostic Criteria, adverse effect, Hemorrhagic, Factor, physician, lack, diagnosed, the disease, suggested, canonical, 【제목키워드】 SARS-CoV-2, Encephalomyelitis,