Background/aim The purpose of this study is to evaluate serum pentraxin-3 (PTX-3) levels in Sars-CoV-2 virus infection (COVID-19) patients and to investigate whether PTX-3 predicts the disease prognosis. Materials and methods This study was conducted on 88 confirmed COVID-19 patients who were hospitalized due to symptomatic pneumonia between April 15 and August 15, 2020. The patients were divided into two groups as survived patients and non-survived patients. Both groups were compared according to demographic features, comorbid conditions and measurement of the PTX-3 and other laboratory parameters of the patients. Results Of 88 patients with COVID-19, 59 (67%) were discharged with complete cure and 29 (33%) resulted in death. 46 (52.3%) of the patients were men. PTX-3 median value (IQR) was 3.66 ng/mL (0.9–27.9) in all patients, 3.3 ng/mL (0.9–27.9) in survivors and 3.91 ng/mL (1.9–23.2) in nonsurvivors which was significantly higher (P = 0.045). As a receiver operating characteristic curve analysis the cut-off value of PTX-3 for predicting mortality in patients was 3.73 with 65% sensitivity and 65% specificity (AUC: 0.646, 95% CI: 0.525–0.767, P = 0.045). Also, we found significant cut-off values with respect to D-dimer, D-dimer/PTX-3, high-sensitivity troponin, high-sensitivity troponin/PTX-3, lymphocyte, PTX-3/lymphocyte, procalcitonin, procalcitonin/PTX-3, CRP, and CRP/PTX-3 (P < 0.05). Conclusion In this study, as far as we know, for the first time, we have shown PTX-3 as the new mortality biomarker for COVID-19 disease.
【저자키워드】 COVID-19, SARS-CoV-2, Mortality, Disease progression, pentraxin, 【초록키워드】 Biomarker, Hospitalized, Prognosis, Pneumonia, CRP, D-dimer, troponin, procalcitonin, SARS-CoV-2 virus, COVID-19 disease, lymphocyte, serum, sensitivity, specificity, Features, symptomatic, Patient, death, virus infection, group, characteristic, patients, predict, Analysis, COVID-19 patient, receiver operating characteristic, complete cure, two groups, both groups, nonsurvivors, receiver, cut-off value, material, comorbid conditions, SARS-CoV-2 virus infection, median value, survivor, Complete, men, laboratory parameter, Result, shown, evaluate, the patient, the disease, conducted, significantly higher, two group, discharged, survived, comorbid condition, IQR, nonsurvivor, patients with COVID-19, 【제목키워드】 Pneumonia, diagnostic, Accuracy, Predictive,