Objectives Cardiac injury is associated with poor prognosis of 2019 novel coronavirus disease 2019 (COVID-19), but the risk factors for cardiac injury have not been fully studied. In this study, we carried out a systematic analysis of clinical characteristics in COVID-19 patients to determine potential risk factors for cardiac injury complicated COVID-19 virus infection. Methods We systematically searched relevant literature published in Pubmed, Embase, Europe PMC, CNKI and other databases. All statistical analyses were performed using STATA 16.0. Results We analysed 5726 confirmed cases from 17 studies. The results indicated that compared with non-cardiac-injured patients, patients with cardiac injury are older, with a greater proportion of male patients, with higher possibilities of existing comorbidities, with higher risks of clinical complications, need for mechanical ventilation, ICU transfer and mortality. Moreover, C-reactive protein, procalcitonin, D-dimer, NT-proBNP and blood creatinine in patients with cardiac injury are also higher while lymphocyte counts and platelet counts decreased. However, we fortuitously found that patients with cardiac injury did not present higher clinical specificity for chest distress ( P = 0.304), chest pain ( P = 0.334), palpitations ( P = 0.793) and smoking ( P = 0.234). Similarly, the risk of concomitant arrhythmia ( P = 0.103) did not increase observably either. Conclusion Age, male gender and comorbidities are risk factors for cardiac injury complicated COVID-19 infection. Such patients are susceptible to complications and usually have abnormal results of laboratory tests, leading to poor outcomes. Contrary to common cardiac diseases, cardiac injury complicated COVID-19 infection did not significantly induce chest distress, chest pain, palpitations or arrhythmias. Our study indicates that early prevention should be applied to COVID-19 patients with cardiac injury to reduce adverse outcomes.
【저자키워드】 COVID-19, coronavirus, cardiac injury, Meta analysis, 【초록키워드】 Europe, Diseases, Mortality, mechanical ventilation, Clinical characteristics, Infection, Comorbidities, Comorbidity, Gender, C-reactive protein, risk, D-dimer, procalcitonin, Laboratory tests, smoking, risk factor, adverse outcomes, ICU, arrhythmia, outcomes, Lymphocyte count, 2019 novel coronavirus, COVID-19 infection, Chest, male, Patient, Platelet, Complication, COVID-19 virus, NT-proBNP, disease, Arrhythmias, patients, Blood, creatinine, Injury, distress, statistical analysis, COVID-19 patient, chest pain, confirmed case, Older, Factor, higher risk, potential risk, clinical specificity, poor prognosis, transfer, Stata, CNKI, clinical complications, systematic analysis, objective, susceptible, palpitation, Result, greater, performed, carried, significantly, proportion, indicated, analysed, indicate, searched, determine, induce, reduce, PMC, 【제목키워드】 Meta-analysis, systematic review, Characteristics, clinical,