Sequence Read Archive submissions to the National Center for Biotechnology Information often lack useful metadata, which limits the utility of these submissions. We describe the Sequence Taxonomic Analysis Tool (STAT), a scalable k- mer-based tool for fast assessment of taxonomic diversity intrinsic to submissions, independent of metadata. We show that our MinHash-based k- mer tool is accurate and scalable, offering reliable criteria for efficient selection of data for further analysis by the scientific community, at once validating submissions while also augmenting sample metadata with reliable, searchable, taxonomic terms. Supplementary Information The online version contains supplementary material available at 10.1186/s13059-021-02490-0.
【저자키워드】 metagenomics, MinHash, 【초록키워드】 Biotechnology, Metadata, Scientific community, utility, STAT, Analysis, criteria, supplementary material, center, submission, Sequence Read Archive, limit, independent, intrinsic, lack, Taxonomic, 【제목키워드】 sequence, submission, K -mer, Sequence Read Archive,