Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and has posed a serious threat to global health. Here, we systematically characterized the transcription levels of the SARS-CoV-2 genes and identified the responsive human genes associated with virus infection. We inferred the possible biological functions of each viral gene and depicted the functional landscape based on guilt-by-association and functional enrichment analyses. Subsequently, the transcription factor regulatory network, protein–protein interaction network, and non-coding RNA regulatory network were constructed to discover more potential antiviral targets. In addition, several potential drugs for COVID-19 treatment and prevention were recognized, including known cell proliferation-related, immune-related, and antiviral drugs, in which proteasome inhibitors (bortezomib, carfilzomib, and ixazomib citrate) may play an important role in the treatment of COVID-19. These results provided novel insights into the understanding of SARS-CoV-2 functional genomics and host-targeting antiviral strategies for SARS-CoV-2 infection. Supplementary Information The online version contains supplementary material available at 10.1186/s13578-021-00684-4.
【초록키워드】 COVID-19, Treatment, SARS-CoV-2, Coronavirus disease 2019, coronavirus, Antiviral, SARS-COV-2 infection, Transcription, antiviral drugs, regulatory network, drug, Infectious disease, biological function, Health, targets, virus infection, inhibitor, antiviral strategy, Protein–protein interaction, transcription factor, acute respiratory syndrome, supplementary material, non-coding RNA, human gene, Functional enrichment analyses, Cell, caused, addition, provided, characterized, functional, bortezomib, the SARS-CoV-2, 【제목키워드】 SARS-CoV-2, antiviral drug, therapeutic target, viral transcriptome, functional,