Background There is an urgent need for highly efficacious antiviral therapies in immunosuppressed hosts who develop coronavirus disease (COVID-19), with special concern for those affected by hematological malignancies. Case presentation Here, we report the case of a 75-year-old male with chronic lymphocytic leukemia who was deficient in CD19 + CD20 + B-lymphocyte populations due to previous treatment with anti-CD20 monoclonal antibodies. The patient presented with severe COVID-19 pneumonia due to prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and was treated with two courses of the antiviral plitidepsin on a compassionate use basis. The patient subsequently achieved an undetectable viral load, and his pneumonia resolved. Conclusions Treatment with plitidepsin was well-tolerated without any further hematological or cardiovascular toxicities. This case further supports plitidepsin as a potential antiviral drug in SARS-CoV-2 patients affected by immune deficiencies and hematological malignancies. Supplementary Information The online version contains supplementary material available at 10.1186/s13045-021-01220-0.
【저자키워드】 COVID-19, SARS-CoV-2, chronic lymphocytic leukemia, Plitidepsin, Anti-CD20 monoclonal antibody, Prolonged viral replication, 【초록키워드】 coronavirus disease, antiviral therapy, Severe COVID-19 pneumonia, coronavirus, COVID-19 pneumonia, Antiviral, Pneumonia, Hematological malignancies, Infection, chronic lymphocytic leukemia, monoclonal antibodies, immune, Population, antiviral drug, Viral, Viral load, male, Patient, Plitidepsin, respiratory, leukemia, compassionate use, CD20, SARS-CoV-2 patients, Immunosuppressed, CD19, Immune deficiencies, antiviral therapies, Support, deficiency, acute respiratory syndrome, supplementary material, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, toxicities, hematological, Lymphocytic leukemia, Host, Course, affected, develop, treated, resolved, SARS-CoV-2 patient, treatment with anti-CD20, undetectable, 【제목키워드】 Treatment, chronic lymphocytic leukemia, B cell, Patient, Plitidepsin, leukemia, SARS-CoV-2 replication, anti-CD20, monoclonal,