Evidence suggests that platelets may directly interact with SARS-CoV-2, raising the concern whether ACE2 receptor plays a role in this interaction. The current study showed that SARS-CoV-2 interacts with both platelets and megakaryocytes despite the limited efficiency. Abundance of the conventional receptor ACE2 and alternative receptors or co-factors for SARS-CoV-2 entry was characterized in platelets from COVID-19 patients and healthy persons as well as human megakaryocytes based on laboratory tests or previously reported RNA-seq data. The results suggest that SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism and may regulate alternative receptor expression associated with COVID-19 coagulation dysfunction. Supplementary Information The online version contains supplementary material available at 10.1186/s13045-021-01082-6.
【저자키워드】 COVID-19, SARS-CoV-2, platelet activation, ACE2, Platelets, Alternative receptors, 【초록키워드】 ACE2 receptor, Laboratory tests, Platelets, Coagulation, Platelet, receptor, expression, mechanism, COVID-19 patients, Interaction, regulate, COVID-19 patient, Efficiency, Laboratory test, coagulation dysfunction, supplementary material, SARS-CoV-2 entry, abundance, RNA-seq data, receptor ACE2, healthy, reported, characterized, interact, raising, with COVID-19, 【제목키워드】 Platelets, Platelet, mechanism, interact,