COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the pathogenesis of severe infections and ARDS and evidence is emerging that the IL-1/IL-6 pathway is highly upregulated in patients with severe disease. These findings open new avenues for host-directed therapies in patients with symptomatic SARS-CoV-2 infection and might in addition to antiviral treatment be enough to curb the currently unacceptably high morbidity and mortality associated with COVID-19.
All Keywords
【초록키워드】 COVID-19, Severe infection, ARDS, Pathogenesis, Infection, Antiviral treatment, Asymptomatic, Patient, pathway, emerging disease, morbidity and mortality, severe pneumonia, acute respiratory distress, Evidence, severe disease, syndrome, symptomatic SARS-CoV-2 infection, host-directed therapy, addition, majority, upregulated, individuals, mild respiratory, with COVID-19, 【제목키워드】 COVID-19, Respiratory failure, IL-1, blocking, Prevent,
【초록키워드】 COVID-19, Severe infection, ARDS, Pathogenesis, Infection, Antiviral treatment, Asymptomatic, Patient, pathway, emerging disease, morbidity and mortality, severe pneumonia, acute respiratory distress, Evidence, severe disease, syndrome, symptomatic SARS-CoV-2 infection, host-directed therapy, addition, majority, upregulated, individuals, mild respiratory, with COVID-19, 【제목키워드】 COVID-19, Respiratory failure, IL-1, blocking, Prevent,