Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.
All Keywords
【저자키워드】 COVID-19, SARS-CoV2, mechanical ventilation, Lung strain, Work of breathing, P-SILI, 【초록키워드】 Lung injury, heterogeneity, Lung function, Patient, Respiratory Support, physiological, Support, Clinical data, approach, robust, Self-Inflicted Lung Injury, responsible, addition, 【제목키워드】 SARS-COV-2 infection, Lung injury, progression, physiological, effort, approach,
【저자키워드】 COVID-19, SARS-CoV2, mechanical ventilation, Lung strain, Work of breathing, P-SILI, 【초록키워드】 Lung injury, heterogeneity, Lung function, Patient, Respiratory Support, physiological, Support, Clinical data, approach, robust, Self-Inflicted Lung Injury, responsible, addition, 【제목키워드】 SARS-COV-2 infection, Lung injury, progression, physiological, effort, approach,