Background To limit the spread of SARS-CoV-2, an evidence-based understanding of the symptoms is critical to inform guidelines for quarantining and testing. The most common features are purported to be fever and a new persistent cough, although the global prevalence of these symptoms remains unclear. The aim of this systematic review is to determine the prevalence of symptoms associated with COVID-19 worldwide. Methods We searched PubMed, Embase, CINAHL, AMED, medRxiv and bioRxiv on 5 th April 2020 for studies of adults (>16 years) with laboratory test confirmed COVID-19. No language or publication status restrictions were applied. Data were independently extracted by two review authors into standardised forms. All datapoints were independently checked by three other review authors. A random-effects model for pooling of binomial data was applied to estimate the prevalence of symptoms, subgrouping estimates by country. I 2 was used to assess inter-study heterogeneity. Results Of 851 unique citations, 148 articles were included which comprised 24,410 adults with confirmed COVID-19 from 9 countries. The most prevalent symptoms were fever (78% [95% CI 75%-81%]; 138 studies, 21,701 patients; I 2 94%), a cough (57% [95% CI 54%-60%]; 138 studies, 21,682 patients; I 2 94%) and fatigue (31% [95% CI 27%-35%]; 78 studies, 13,385 patients; I 2 95%). Overall, 19% of hospitalised patients required non-invasive ventilation (44 studies, 6,513 patients), 17% required intensive care (33 studies, 7504 patients), 9% required invasive ventilation (45 studies, 6933 patients) and 2% required extra-corporeal membrane oxygenation (12 studies, 1,486 patients). The mortality rate was 7% (73 studies, 10,402 patients). Conclusions We confirm that fever and cough are the most prevalent symptoms of adults infected by SARS-CoV-2. However, there is a large proportion of infected adults which symptoms-alone do not identify.
【초록키워드】 COVID-19, SARS-CoV-2, intensive care, fatigue, systematic review, Symptom, cough, invasive ventilation, Symptoms, heterogeneity, Laboratory, Spread, Prevalence, Fever, non-invasive ventilation, Hospitalised patients, mortality rate, pooling, estimate, Critical, patients, Extra-corporeal membrane oxygenation, Laboratory test, persistent cough, 95% CI, CINAHL, medRxiv, these symptoms, random-effects model, AMED, binomial data, bioRxiv, article, forms, country, feature, limit, prevalent, Result, identify, was used, proportion, required, applied, searched, determine, unique, hospitalised patient, checked, authors, datapoint, these symptom, with COVID-19, 【제목키워드】 Meta-analysis, systematic review, Symptom, Novel coronavirus, Prevalence, country,