ABSTRACT The recent emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a significant concern for public health worldwide. New variants have been classified either as variants of concern (VOCs) or variants of interest (VOIs) by the CDC (USA) and WHO. The VOCs include lineages such as B.1.1.7 (20I/501Y.V1 variant), P.1 (20J/501Y.V3 variant), B.1.351 (20H/501Y.V2 variant), and B.1.617.2. In contrast, the VOI category includes B.1.525, B.1.526, P.2, and B.1.427/B.1.429. The WHO provided the alert for last two variants (P.2 and B.1.427/B.1.429) and labeled them for further monitoring. As per the WHO, these variants can be reclassified due to their status at a particular time. At the same time, the CDC (USA) has marked these two variants as VOIs up through today. This article analyzes the evolutionary patterns of all these emerging variants, as well as their geographical distributions and transmission patterns, including the circulating frequency, entropy diversity, and mutational event diversity throughout the genomes of all SARS-CoV-2 lineages. The transmission pattern was observed highest in the B.1.1.7 lineage. Our frequency evaluation found that this lineage achieved 100% frequency in early October 2020. We also critically evaluated the above emerging variants mutational landscape and significant spike protein mutations (E484K, K417T/N, N501Y, and D614G) impacting public health. Finally, the effectiveness of vaccines against newly SARS-CoV-2 variants was also analyzed.
【저자키워드】 emerging variants, transmission pattern, mutational landscape, effect on vaccines, 【초록키워드】 public health, SARS-CoV-2, Vaccine, coronavirus, Mutation, VoC, B.1.351, Genome, variant, SARS-CoV-2 variant, variants of concern, B.1.617.2, Transmission, severe acute respiratory syndrome Coronavirus, variants, Spike protein, B.1.1.7 lineage, CDC, B.1.1.7, N501Y, P.1, VOCs, Lineage, Effectiveness, D614G, P.2, variants of interest, E484K, WHO, B.1.526, genomes, VOIs, respiratory, USA, lineages, Frequency, VOI, geographical distribution, geographical distributions, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, circulating, today, B.1.525, transmission patterns, highest, analyzed, include, evaluated, provided, the WHO, New, 【제목키워드】 SARS-CoV-2, mode, landscape,