Highlights • Time trend of SARS-CoV-2 and time trend of other respiratory pathogens. • SARS-CoV-2 real time RT-PCR. • Multiplex PCR assay for Respiratory pathogens. • SARS-CoV-2 virus did not affect the time trend of other respiratory infections. In Italy, the first SARS-CoV-2 infections were diagnosed in Rome, Lazio region, at the end of January 2020, but sustained transmission occurred later, since the end of February. From 1 February to 12 April 2020, 17,164 nasopharyngeal swabs were tested by real time PCR for the presence of SARS-CoV-2 at the Laboratory of Virology of National Institute for Infectious Diseases “Lazzaro Spallanzani” (INMI) in Rome. In the same period, coincident with the winter peak of influenza and other respiratory illnesses, 847 samples were analyzed by multiplex PCR assay for the presence of common respiratory pathogens. In our study the time trend of SARS-CoV-2 and that of other respiratory pathogens in the same observation period were analysed. Overall, results obtained suggest that the spread of the pandemic SARS-CoV-2 virus did not substantially affect the time trend of other respiratory infections in our region, highlighting no significant difference in rates of SARS-CoV-2 infection in patients with or without other respiratory pathogens. Therefore, in the present scenario of COVID-19 pandemic, differential diagnosis resulting positive for common respiratory pathogen(s) should not exclude testing of SARS-CoV-2.
【저자키워드】 SARS-CoV-2, Respiratory pathogens, Trend of infection, 【초록키워드】 pandemic, Virology, Influenza, SARS-COV-2 infection, COVID-19 pandemic, Multiplex PCR, SARS-CoV-2 virus, Transmission, Infectious disease, Italy, RT-PCR, Spread, Nasopharyngeal swab, PCR, Patient, Pathogens, respiratory illnesses, respiratory, differential diagnosis, real time, no significant difference, respiratory pathogen, other respiratory infections, observation period, PCR assay, Rome, positive, Lazio, Affect, time, resulting, tested, analyzed, occurred, diagnosed, analysed, not affect, other respiratory infection, sustained, highlighting, INMI, 【제목키워드】 trend, COVID-19 epidemic, respiratory pathogen,