Description Unique circulating regulatory T cell phenotypes distinguish hospitalized patients with SARS-CoV-2. Despite recent studies of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), little is known about how the immune response against SARS-CoV-2 differs from other respiratory infections. We compare the immune signature from hospitalized SARS-CoV-2–infected patients to patients hospitalized prepandemic with influenza or respiratory syncytial virus (RSV). Our in-depth profiling indicates that the immune landscape in SARS-CoV-2 patients is largely similar to flu or RSV patients. Unique to patients infected with SARS-CoV-2 who had the most critical clinical disease were changes in the regulatory T cell (T reg ) compartment. A T reg signature including increased frequency, activation status, and migration markers was correlated COVID-19 severity. These findings are relevant as T regs are considered for therapy to combat the severe inflammation seen in COVID-19 patients. Likewise, having defined the overlapping immune landscapes in SARS-CoV-2, existing knowledge of flu and RSV infections could be leveraged to identify common treatment strategies.
【초록키워드】 SARS-CoV-2, coronavirus, immune response, therapy, Hospitalized, Immunity, Influenza, knowledge, COVID-19 severity, immune, Regulatory, T cell, Migration, respiratory syncytial virus, RSV, Patient, flu, Critical, patients, COVID-19 patients, marker, Frequency, overlapping, acute respiratory syndrome, Activation, Treatment strategies, other respiratory infections, T cell phenotype, circulating, description, severe inflammation, clinical disease, immune signature, defined, identify, indicate, changes in, hospitalized patient, correlated, RSV infection, infected with SARS-CoV-2, patients hospitalized, SARS-CoV-2 patient, SARS-CoV-2–infected patient, 【제목키워드】 immune, Regulatory, T cell, COVID-19 patient, other respiratory infection,