Highlights • Evolution of global PEDV strains. • Cross-reactivity between PEDV and other coronaviruses and antigenic variations among different PEDV strains. • Pathologic features of different PEDV strains. • Considerations for vaccine strain selection: PEDV virulence attenuation and in vivo cross-protection among PEDV variants. Emerging and re-emerging coronaviruses cause morbidity and mortality in human and animal populations, resulting in serious public and animal health threats and economic losses. The ongoing outbreak of a highly contagious and deadly porcine epidemic diarrhea virus (PEDV) in Asia, the Americas and Europe is one example. Genomic sequence analyses of PEDV variants have revealed important insights into the evolution of PEDV. However, the antigenic variations among different PEDV strains are less explored, although they may contribute to the failure of PEDV vaccines in Asian countries. In addition, the evolution of PEDV results in variants with distinct genetic features and virulence differences; thus PEDV can serve as a model to explore the molecular mechanisms of coronavirus evolution and pathogenesis. In this article, we review the evolution, antigenic relationships and pathologic features of PEDV strains. This information and review of researches will aid in the development of strategies for control and prevention of PED.
【저자키워드】 Evolution, coronavirus, cross-protection, cross-reactivity, antigenicity, ELISA, enzyme-linked immunosorbent assay, N, nucleocapsid, S, spike, RBD, receptor binding domain, IFN, interferon, pathogenicity, Porcine epidemic diarrhea virus, NTD, N-terminal domain, ORF, open reading frame, E, Envelope, mAb, monoclonal antibody, Porcine epidemic diarrhea, US, United States, WT, wild type, M, membrane, aa, amino acid, CCIF, cell culture immunofluorescence assay, CDCD, cesarean-derived, colostrum-deprived, DPI, days post-inoculation, FIPV, feline infectious peritonitis virus, HPI, hours post-inoculation, IHC, immunohistochemistry, INDEL, insertions and deletions, nt, nucleotide, PDCoV, porcine deltacoronavirus, PED, porcine epidemic diarrhea, PEDV, porcine epidemic diarrhea virus, PFU, plaque-forming unit, PRCV, porcine respiratory coronavirus, TC, tissue culture-adapted, TCID50, 50% tissue culture infectious dose, TGEV, transmissible gastroenteritis virus, VH:CD, villus height versus crypt depth ratio, VN, viral neutralization, 【초록키워드】 Vaccine, coronavirus, Europe, Pathogenesis, threat, Genetic, variant, molecular mechanism, virus, variants, Asia, Health, outbreak, morbidity and mortality, in vivo, information, virulence, Strains, Analysis, antigenic variation, strain, epidemic diarrhea, Asian, antigenic, sequence, PEDV, America, contagious, vaccine strain, populations, feature, resulting, example, addition, other coronavirus, less, contribute, pathologic feature, 【제목키워드】 epidemic diarrhea, virus strain,