Highlights • Evolutionary lineage of zoonotic viral cross-species transmission of the Coronaviridae. • The role of human microbiome in predicting and controlling infectious diseases. • Importance of synthetic viruses in the study of viral evolution and transmission. The outbreak and spread of new strains of coronavirus (SARS-CoV-2) remain a global threat with increasing cases in affected countries. The evolutionary tree of SARS-CoV-2 revealed that Porcine Reproductive and Respiratory Syndrome virus 2, which belongs to the Beta arterivirus genus from the Arteriviridae family is possibly the most ancient ancestral origin of SARS-CoV-2 and other Coronaviridae . This review focuses on phylogenomic distribution and evolutionary lineage of zoonotic viral cross-species transmission of the Coronaviridae family and the implications of bat microbiome in zoonotic viral transmission and infection. The review also casts light on the role of the human microbiome in predicting and controlling viral infections. The significance of microbiome-mediated interventions in the treatment of viral infections is also discussed. Finally, the importance of synthetic viruses in the study of viral evolution and transmission is highlighted.
【저자키워드】 COVID-19, viral infection, zoonotic infection, human microbiome, Zoonotic evolution, Synthetic virus, 【초록키워드】 Treatment, SARS-CoV-2, coronavirus, Diseases, Infection, Intervention, Transmission, virus, viral infections, Spread, outbreak, viral evolution, zoonotic, Microbiome, Lineage, Beta, Viral transmission, respiratory, distribution, Coronaviridae, Cross-species transmission, new strain, arterivirus, implication, affected, Importance, the Coronaviridae, 【제목키워드】 Evolution, Infection, Transmission, Microbiome, implication, in viral,