Highlights • SARS-CoV-2 is currently causing a major pandemic called COVID-19. • SARS-CoV-2 affects almost any organ due to the presence of ACE2 receptor. • Immunological co-ordination between gut and the lungs facilitates SARS-CoV-2 to infect GI tract. • Viral RNA of SARS-CoV-2 is detected in stool samples of COVID-19 patients. • There exist possibilities of transmission of SARS-CoV-2 via fecal-oral route. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a major pandemic called coronavirus disease 2019 (COVID-19) that has created unprecedented global health emergencies, and emerged as a serious threat due to its strong ability for human-to-human transmission. The reports indicate the ability of SARS-CoV-2 to affect almost any organ due to the presence of a receptor known as angiotensin converting enzyme 2 (ACE2) across the body. ACE2 receptor is majorly expressed in the brush border of gut enterocytes along with the ciliated cells and alveolar epithelial type II cells in the lungs. The amino acid transport function of ACE2 has been linked to gut microbial ecology in gastrointestinal (GI) tract, thereby suggesting that COVID-19 may, to some level, be linked to the enteric microbiota. The significant number of COVID-19 patients shows extra-pulmonary symptoms in the GI tract. Many subsequent studies revealed viral RNA of SARS-CoV-2 in fecal samples of COVID-19 patients. This presents a new challenge in the diagnosis and control of COVID-19 infection with a caution for proper sanitation and hygiene. Here, we aim to discuss the immunological co-ordination between gut and lungs that facilitates SARS-CoV-2 to infect and multiply in the inflammatory bowel disease (IBD) and non-IBD patients.
【저자키워드】 COVID-19, SARS-CoV-2, ACE2, Inflammatory bowel disease, gastrointestinal tract, gut–lung axis, 【초록키워드】 coronavirus disease, coronavirus, pandemic, Diagnosis, lung, ACE2 receptor, Symptom, RNA, Health, microbiota, COVID-19 infection, Lungs, Fecal sample, Viral RNA, receptor, epithelial, patients, COVID-19 patients, IBD, GI Tract, Amino acid, COVID-19 patient, Gut, hygiene, Transport, acute respiratory syndrome, ciliated cell, enzyme, human-to-human transmission, organ, transmission of SARS-CoV-2, alveolar, infect, Affect, immunological, Cell, subsequent, facilitate, expressed, Enterocyte, detected in stool, gut microbial ecology, 【제목키워드】 SARS-COV-2 infection, lung, Gut,