The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is having a disastrous impact on global health. Recently, several studies examined the potential of vitamin D to reduce the effects of SARS-CoV-2 infection by modulating the immune system. Indeed, vitamin D has been found to boost the innate immune system and stimulate the adaptive immune response against SARS-CoV-2 infection. In this review, we provide a comprehensive update of the immunological mechanisms underlying the positive effects of vitamin D in reducing SARS-CoV-2 infection as well as a thorough survey of the recent epidemiological studies and clinical trials that tested vitamin D as a potential therapeutic agent against COVID-19 infection. We believe that a better understanding of the histopathology and immunopathology of the disease as well as the mechanism of vitamin D effects on COVID-19 severity will ultimately pave the way for a more effective prevention and control of this global pandemic.
【저자키워드】 COVID-19, SARS-CoV-2, immune response, Vitamin D, Immunopathogenesis, 【초록키워드】 coronavirus, clinical trial, pandemic, SARS-COV-2 infection, COVID-19 severity, immunopathology, immune system, Histopathology, innate immune system, global pandemic, Health, COVID-19 infection, therapeutic, Adaptive immune response, mechanism, boost, immunological mechanism, acute respiratory syndrome, Epidemiological study, positive, Effect, effective, tested, examined, the disease, reducing, reduce, stimulate, modulating, 【제목키워드】 reducing,