Highlights • Common viruses caused two-fifths of respiratory-illness-related hospitalizations, amidst a COVID-19 outbreak. • The co-infection rate between SARS-CoV-2 and other respiratory viruses was low, at 1.4%. • No increased morbidity or mortality with COVID-19 co-infections. • In-hospital mortality and intubation lower for COVID-19 compared with other respiratory viruses. Aims During the ongoing COVID-19 outbreak, co-circulation of other common respiratory viruses can potentially result in co-infections; however, reported rates of co-infections for SARS-CoV-2 vary. We sought to evaluate the prevalence and etiology of all community acquired viral respiratory infections requiring hospitalization during an ongoing COVID-19 outbreak, with a focus on co-infection rates and clinical outcomes. Methods Over a 10-week period, all admissions to our institution, the largest tertiary hospital in Singapore, were screened for respiratory symptoms, and COVID-19 as well as a panel of common respiratory viral pathogens were systematically tested for. Information was collated on clinical outcomes, including requirement for mechanical ventilation and in hospital mortality. Results One-fifth (19.3%, 736/3807) of hospitalized inpatients with respiratory symptoms had a PCR-proven viral respiratory infection; of which 58.5% (431/736) tested positive for SARS-CoV-2 and 42.2% (311/736) tested positive for other common respiratory viruses. The rate of co-infection with SARS-CoV-2 was 1.4% (6/431); all patients with co-infection had mild disease and stayed in communal settings. The in-hospital mortality rate and proportion of COVID-19 patients requiring invasive ventilation was low, at around 1% of patients; these rates were lower than patients with other community-acquired respiratory viruses admitted over the same period (p < 0.01). Conclusion Even amidst an ongoing COVID-19 outbreak, common respiratory viruses still accounted for a substantial proportion of hospitalizations. Coinfections with SARS-CoV-2 were rare, with no observed increase in morbidity or mortality.
【저자키워드】 COVID-19, Co-infections, respiratory viral infections, Community-acquired, 【초록키워드】 SARS-CoV-2, Hospitalized, Mortality, mechanical ventilation, Hospitalization, hospital, intubation, virus, invasive ventilation, clinical outcomes, respiratory viruses, Prevalence, Coinfection, COVID-19 outbreak, pathogen, respiratory virus, morbidity, hospitalizations, Patient, Co-infection, Community, Mild, Singapore, etiology, disease, Admission, COVID-19 patient, respiratory symptoms, Inpatient, in-hospital mortality rate, respiratory symptom, positive, viral respiratory infection, over, respiratory viral, common, Result, tested, evaluate, caused, proportion, reported, screened, accounted, increase in, viral respiratory, other respiratory virus, with COVID-19, 【제목키워드】 Hospitalized, Clinical outcome, COVID-19 outbreak, Co-infection, Inpatient, viral respiratory infection,