The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, Innate immunity, ISG, IFN alpha/beta, IFN lambda, 【초록키워드】 COVID-19 severity, interferon, Patient, IFN, respiratory tract, Oropharyngeal, expression, ISGs, IFNs, Invasive mechanical ventilation, IRF7, COVID-19 patient, type I, healthy controls, Genes, Cell, decrease, Course, stimulated, defined, required, expressed, SARS-CoV-2 positive patient, 【제목키워드】 coronavirus disease, interferon, Patient, upper respiratory tract, type I,
【저자키워드】 COVID-19, SARS-CoV-2, Innate immunity, ISG, IFN alpha/beta, IFN lambda, 【초록키워드】 COVID-19 severity, interferon, Patient, IFN, respiratory tract, Oropharyngeal, expression, ISGs, IFNs, Invasive mechanical ventilation, IRF7, COVID-19 patient, type I, healthy controls, Genes, Cell, decrease, Course, stimulated, defined, required, expressed, SARS-CoV-2 positive patient, 【제목키워드】 coronavirus disease, interferon, Patient, upper respiratory tract, type I,