Abstract
We aimed to determine prevalence and characteristics of anticardiolipin antibodies (ACLs) and its correlations with laboratory coagulation variables in patients with coronavirus disease 2019 (COVID-19). We retrospectively analyzed the prevalence of serum ACLs and its correlation with coagulative laboratory variables in 87 patients with COVID-19. ACLs were detected in 13/21 (61.91%) critically ill patients, and 21/66 (31.82%) in non-critically ill patients. For ACLs, IgA, and IgG were the most common types. The prevalence of IgG in critical ill patients was much higher than that in non-critical patients with odd ratio = 2.721. And the levels of all isotypes of ACLs in critically ill patients were much higher than those in non-critically ill patients. Correlation analysis showed that activated partial thromboplastin time and thrombin time had weak correlation with ACLs-IgG (R = 0.308, P = .031; R = 0.337, P = .018, respectively). Only the prevalence of ACLs-IgG shows a significant difference when compared critically ill patients with non-critically ill patients. ACLs do not seem to have a clear correlation with thrombosis occurred in COVID-19 patients.
【초록키워드】 COVID-19, coronavirus disease, IgG, thrombosis, antibody, Laboratory, Coagulation, Prevalence, serum, Characteristics, IgA, Patient, correlation, Critical, critically ill patients, COVID-19 patients, Analysis, thrombin, Critically ill patient, significant difference, isotype, variable, non-critically ill patients, analyzed, occurred, activated, determine, much higher, coagulative, ill patient, patients with COVID-19, 【제목키워드】 antibody, Coagulation, correlation, patients with COVID-19,