Objective and design Fecal calprotectin (CLP) is widely known for its detection in stools of patients with inflammatory bowel diseases (IBDs), to investigate the intestinal inflammatory status. Current research is promoting the circulating protein role as a systemic inflammatory marker. However, most studies report serum calprotectin analysis although plasma assay prevents its massive release by granulocytes. In this perspective, the ongoing SARS-CoV-2 pandemic deserves deployment of convenient and easy-to-dose markers that could reliably address the state of infection. Methods We analyzed serum circulating calprotectin (cCLP) levels in hospitalized COVID-19 patients and plasma cCLP levels from patients with suspected SARS-CoV-2 infection, then assessed negative or positive on molecular tests. Results Our results confirm a significant circulating calprotectin increase in infected subjects respect to controls, in serum and plasma. Moreover, plasma calprotectin has higher levels in suspected patients with positive SARS-CoV-2-RT-PCR, compared to suspected patients with negative SARS-CoV-2-RT-PCR. Furthermore, ROC curves results showed the circulating plasma calprotectin discriminatory ability to differentiate infected SARS-CoV-2 patients at a cutoff value greater than 131.3 ng/ml. Conclusions Our data propose circulating calprotectin as a new, quantitative and predictive marker, which in addition to being an interesting generic inflammatory marker may provide important indications in SARS-CoV-2 infection.
【저자키워드】 COVID-19, SARS-CoV-2, Laboratory medicine, Circulating calprotectin, Inflammatory marker, 【초록키워드】 Granulocytes, SARS-COV-2 infection, SARS-CoV-2 pandemic, Infection, RT-PCR, Inflammatory bowel disease, Protein, serum, Stool, Research, Patient, plasma, Quantitative, calprotectin, Molecular tests, hospitalized COVID-19 patient, marker, Analysis, Inflammatory, inflammatory bowel diseases, ROC Curve, Predictive, hospitalized COVID-19 patients, subject, Perspective, indication, stools, circulating, ROC curves, cutoff value, positive, suspected patients, inflammatory status, serum and plasma, objective, Prevent, controls, intestinal, current, systemic inflammatory, Result, greater, analyzed, addition, increase in, SARS-CoV-2 patient, suspected patient, 【제목키워드】 marker, Inflammatory,