Background This study was conducted to evaluate the anti‐SARS‐CoV‐2 IgM and IgG antibodies among healthcare workers in Guilan. Methods This cross-sectional study was conducted on 503 healthcare workers. Between April and May 2020, blood samples were collected from the healthcare workers of Razi Hospital in Rasht, Guilan, Iran. Enzyme-linked immunosorbent assay (ELISA) was used for the detection and quantitation of anti‐SARS‐CoV‐2 IgM/IgG antibodies by using kits made by Pishtaz Teb Company, Tehran, Iran. Results From a total of 503 participants, the result of the anti‐SARS‐CoV‐2 IgM antibody test was positive in 28 subjects (5.6%) and the anti‐SARS‐CoV‐2 IgG antibody test was positive in171 subjects (34%). Participants in the age group of 35–54 years were significantly more likely to have a positive anti‐SARS‐CoV‐2 antibody test than the age group of 20–34 years (odds ratio = 1.53, 95% CI: 1.04–2.25, P =0.029). Also, physicians were significantly more likely to have a positive antibody test than office workers (odds ratio = 1.92, 95% CI: 1.04–3.54, P =0.037). The wide range of symptoms was significantly associated with the positive anti‐SARS‐CoV‐2 antibody test. The most significant association was observed between fever and a positive anti‐SARS‐CoV‐2 antibody test (odds ratio = 3.03, 95% CI: 2.06–4.44, P < 0.001). Conclusion The results of the current study indicated that the seroprevalence of COVID-19 was high among healthcare workers of Guilan Province. It seems that this finding was due to the earlier exposure to COVID-19 and the lack of awareness and preparedness to deal with the pandemic in Iran, compared to other countries.
【초록키워드】 COVID-19, pandemic, Healthcare workers, antibody, cross-sectional, Seroprevalence, Symptom, healthcare worker, ELISA, enzyme-linked immunosorbent assay, Iran, cross-sectional study, IgG antibody, IgG antibodies, IgM/IgG, healthcare, Fever, Awareness, age, Antibody test, association, Odds ratio, exposure to, lack of awareness, Participants, 95% CI, Blood samples, subject, enzyme, blood sample, participant, physician, quantitation, positive, Tehran, company, anti‐SARS‐CoV‐2 IgM, Rasht, Result, was used, lack, collected, evaluate, significantly more, significantly, indicated, conducted, anti‐SARS‐CoV‐2 IgG, 【제목키워드】 SARS-CoV-2,