Abstract
Background: COVID-19 convalescent plasma (CCP) was approved under emergency authorization to treat critically ill patients with COVID-19 in the United States in 2020. We explored the demographics of donors contributing plasma for a hyperimmune, plasma-derived therapy to evaluate factors that may be associated with anti-SARS-CoV-2 antibody response variability and, subsequently, antibody titers.
Study design: An electronic search of CCP donors was performed across 282 US plasma donation centers. Donations were screened for nucleocapsid protein-binding-IgG using the Abbott SARS-CoV-2 IgG assay.
Results: Overall, 52 240 donors donated 418 046 units of CCP. Donors were of various ethnicities: 43% Caucasian, 34% Hispanic, 17% African American, 2% Native American, 1% Asian, and 3% other. Females had higher initial mean anti-SARS-CoV-2 antibody titers but an overall faster rate of decline (P < .0001). Initial antibody titers increased with age: individuals aged 55 to 66 years had elevated anti-SARS-CoV-2 titers for longer periods compared with other ages (P = .0004). African American donors had the lowest initial antibody titers but a slower rate of decline (P < .0001), while Caucasian (P = .0088) and Hispanic (P = .0193) groups had the fastest rates of decline. Most donor antibody levels decreased below the inclusion criteria (≥1.50) within 30 to 100 days of first donation, but donation frequency did not appear to be associated with rate of decline.
Conclusion: Several factors may be associated with anti-SARS-CoV-2 antibody response including donor age and sex. Evaluating these factors during development of future hyperimmune globulin products may help generation of therapies with optimal efficacy.
Keywords: SARS-CoV-2; convalescent COVID-19 plasma; hyperimmune globulins; plasma donor demographics.
【저자키워드】 SARS-CoV-2, plasma donor demographics., hyperimmune globulins, convalescent COVID-19 plasma, 【초록키워드】 COVID-19, convalescent plasma, Efficacy, therapy, antibody, anti-SARS-CoV-2 antibody, nucleocapsid, Antibody titer, plasma, age, convalescent, group, African American, Antibody titers, Donor, Hispanic, Frequency, donation, demographics, CCP, Critically ill patient, Asian, Factor, individual, Variability, inclusion criteria, help, treat, MOST, Abbott SARS-CoV-2 IgG, hyperimmune, initial, lowest, evaluate, the United State, approved, elevated, was performed, screened, faster, age and sex, anti-SARS-CoV-2 titer, Evaluating, Native, with COVID-19, 【제목키워드】 COVID-19, antibody, plasma, age, convalescent, Donor, association, initial,