Abstract
Antibody testing after COVID-19 vaccination is generally not recommended. Here, we present the results of a retrospective study, in which we analyzed antibody levels before and after the first dose of the ChAdOx1 vector vaccine. We identified 5% non-responders (43.6 ± 10.6 years; females: 41%) and 3.4% low-responders (44.2 ± 10.1 years; females: 64%) after the first dose. Of these, 61 individuals received a timely second dose either with a homologous (ChAdOx1/ChAdOx1) or heterologous (ChAdOx1/mRNA-1273) schedule. All vaccinees achieved positive S1-specific IgG titers to the ancestral SARS-CoV-2 strain after the second dose, but antibody levels as well as neutralization titers against the ancestral SARS-CoV-2 strain were higher after the heterologous schedule. However, Omicron-specific neutralizing antibodies were not detectable after two doses in either group, indicating that a third vaccine dose is needed to enhance cross-reactive antibodies against currently circulating and emerging variants of concern.
Keywords: Antibody testing; COVID-19; Heterologous COVID-19 vaccine schedule; Humoral immune response; Initial non/low responder; Vaccination strategy.
【저자키워드】 COVID-19, Antibody testing, humoral immune response, Vaccination strategy., Initial non/low responder, Heterologous COVID-19 vaccine schedule, 【초록키워드】 neutralizing antibody, COVID-19 vaccine, antibody, variants of concern, immune, vaccine dose, Retrospective study, COVID-19 vaccination, homologous, Heterologous, IgG titer, dose, cross-reactive antibody, second dose, first dose, individual, circulating, positive, neutralization titer, SARS-CoV-2 strain, non-responder, vaccinee, ENhance, analyzed, detectable, ChAdOx1 vector vaccine, 【제목키워드】 antibody, Seroconversion, COVID-19 vaccination, Heterologous, non-responder, initial,