Abstract
This study assessed T-cell responses in individuals with and without a positive antibody response to SARS-CoV-2, in symptomatic and asymptomatic individuals during the COVID-19 pandemic. Participants were drawn from the TwinsUK cohort, grouped by (a) presence or absence of COVID-associated symptoms (S+, S-), logged prospectively through the COVID Symptom Study app, and (b) anti-IgG Spike and anti-IgG Nucleocapsid antibodies measured by ELISA (Ab+, Ab-), during the first wave of the UK pandemic. T-cell helper and regulatory responses after stimulation with SARS-CoV-2 peptides were assessed. Thirty-two participants were included in the final analysis. Fourteen of 15 with IgG Spike antibodies had a T-cell response to SARS-CoV-2-specific peptides; none of 17 participants without IgG Spike antibodies had a T-cell response (χ 2 : 28.2, p < 0.001). Quantitative T-cell responses correlated strongly with fold-change in IgG Spike antibody titer (ρ = 0.79, p < 0.0001) but not to symptom score (ρ = 0.17, p = 0.35). Humoral and cellular immune responses to SARS-CoV-2 are highly correlated. We found no evidence of cellular immunity suggestive of SARS-CoV2 infection in individuals with a COVID-19-like illness but negative antibodies.
Keywords: SARS-CoV-2; T cell; antibody; symptom response.
【저자키워드】 SARS-CoV-2, antibody, T cell, symptom response., 【초록키워드】 antibodies, IgG, pandemic, spike, Cellular immune response, COVID-19 pandemic, T-cell Response, Symptom, SARS-CoV2 infection, ELISA, COVID, Regulatory, Cohort, cellular immunity, response, Antibody titer, T-cell, First wave, Evidence, Analysis, individual, participant, Final, positive antibody response, anti-IgG, absence, correlated, correlated strongly, SARS-CoV-2 peptide, symptomatic and asymptomatic, TwinsUK, were assessed, 【제목키워드】 COVID-19, SARS-COV-2 infection, T-cell Response, Symptom,