Abstract
Because a large proportion of the Austrian population has been infected with SARS-CoV-2 during high incidence periods in winter 2021/2022, up-to-date estimates of seroprevalence of anti-SARS-CoV-2 antibodies are required to inform upcoming public health policies. We quantified anti-Spike IgG antibody levels in 22,607 individuals that donated blood between October 2021 and April 2022 across Tyrol, Austria (participation rate: 96.0%). Median age of participants was 45.3 years (IQR: 30.9-55.1); 41.9% were female. From October 2021 to April 2022, seropositivity increased from 84.9% (95% CI: 83.8-86.0%) to 95.8% (94.9-96.4%), and the geometric mean anti-Spike IgG levels among seropositive participants increased from 283 (95% CI: 271-296) to 1437 (1360-1518) BAU/mL. The percentages of participants in categories with undetectable levels and detectable levels at <500, 500-<1000, 1000-<2000, 2000-<3000, and ≥3000 BAU/mL were 15%, 54%, 15%, 10%, 3%, and 3% in October 2021 vs. 4%, 18%, 17%, 18%, 11%, and 32% in April 2022. Of 2711 participants that had repeat measurements taken a median 4.2 months apart, 61.8% moved to a higher, 13.9% to a lower, and 24.4% remained in the same category. Among seropositive participants, antibody levels were 16.8-fold in vaccinated individuals compared to unvaccinated individuals (95% CI: 14.2-19.9; p -value < 0.001). In conclusion, anti-SARS-CoV-2 seroprevalence in terms of seropositivity and average antibody levels has increased markedly during the winter 2021/2022 SARS-CoV-2 waves in Tyrol, Austria.
Keywords: SARS-CoV-2; anti-spike IgG antibodies; blood donors; seroprevalence.
【저자키워드】 SARS-CoV-2, Seroprevalence, Blood donors, anti-spike IgG antibodies, 【초록키워드】 public health, antibody, anti-SARS-CoV-2, IgG antibody, anti-SARS-CoV-2 antibody, anti-Spike IgG, female, age, incidence, estimate, Blood, individual, average, P -value, participant, seropositive participants, vaccinated individual, proportion, remained, detectable, required, median, category, quantified, geometric, IgG level, infected with SARS-CoV-2, percentage, seropositive participant, undetectable, 【제목키워드】 IgG, Seroprevalence, Period, Covering, Involving,