Abstract
Preexisting immunity cross-reactive to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in SARS-CoV-1 survivors suggests that a coronavirus disease 2019 vaccine may boost such preexisting cross-reactive memory T cells. We measure SARS-CoV-2 and SARS-CoV-1 spike-specific neutralizing antibody and T cell responses in a single dose of Ad5-nCoV-immunized SARS-CoV-1 survivors 6 months after vaccination. Compared with Ad5-nCoV-immunized naive healthy individuals (NHIs), vaccination of Ad5-nCoV in SARS-CoV-1 survivors boosts the antibody response against SARS-CoV-1 but induces a limited neutralizing antibody that is capable of neutralizing SARS-CoV-2 variants of concern, and nearly all serum samples lose neutralization to Omicron subvariants. Immunized SARS-CoV-1 survivors produce a T cell response to SARS-CoV-2 comparable with that of Ad5-nCoV-immunized NHIs. However, a robust cross-reactive T cell response to SARS-CoV-1 is identified in immunized SARS-CoV-1 survivors compared with Ad5-nCoV-immunized NHIs. These findings suggest that vaccination with Ad5-nCoV elicits a stronger neutralizing antibody and cross-reactive T cell responses against SARS-CoV-1 in SARS-CoV-1 survivors.
Keywords: CP: Immunology; SARS-CoV-1 survivors; SARS-CoV-2; T cells; antibody; neutralization; vaccination; variants of concern.
【저자키워드】 SARS-CoV-2, vaccination, antibody, T cells, neutralization, variants of concern, CP: Immunology, SARS-CoV-1 survivors, 【초록키워드】 coronavirus disease, neutralizing antibody, Vaccine, Immunity, SARS-CoV-2 variant, variants of concern, omicron, SARS-CoV-1, Survivors, memory T cells, Neutralizing, T cell response, boost, single dose, Coronavirus-2, cross-reactive, acute respiratory syndrome, serum sample, survivor, immunized, robust, elicit, induce, comparable, the antibody response, healthy individual, 【제목키워드】 SARS-CoV-1, T cell response, survivor,