Abstract
We aimed to evaluate the correlation of plasma levels of thiobarbituric acid reactive substances (TBARS) and reduced thiols with morbidity, mortality and immune response during and after SARS-CoV-2 infection. This was an observational study that included inpatients with SARS-CoV-2 infection older than 65 years. The individuals were followed up to the twelfth month post-discharge. Plasma levels of TBARS and reduced thiols were quantified as a measure of lipid and protein oxidation, respectively. Fatal and non-fatal events were evaluated during admission and at the third, sixth and twelfth month post-discharge. Differences in oxidative stress markers between the groups of interest, time to a negative RT-qPCR and time to significant anti-SARS-CoV-2 IgM titers were assessed. We included 61 patients (57% women) with a mean age of 83 years old. After multivariate analysis, we found differences in TBARS and reduced thiol levels between the comparison groups in fatal and non-fatal events during hospital admission. TBARS levels were also correlated with fatal events at the 6th and 12th months post-discharge. One year after hospital discharge, other predictors rather than oxidative stress markers were relevant in the models. The median time to reach significant anti-SARS-CoV-2 IgM titers was lower in patients with low levels of reduced thiols. Assessment of some parameters related to oxidative stress may help identify groups of patients with a higher risk of morbidity, mortality and delayed immune response during and after SARS-CoV-2 infection.
【초록키워드】 immune response, Mortality, SARS-COV-2 infection, oxidative stress, Protein, RT-qPCR, morbidity, Patient, plasma, age, Hospital admission, women, predictor, correlation, assessment, group, Admission, anti-SARS-CoV-2 IgM, marker, Analysis, Inpatient, Older, higher risk, median time, individual, hospital discharge, help, parameter, event, difference, reactive, identify, evaluate, evaluated, reduced, correlated, quantified, Plasma level, TBARS, were assessed, 【제목키워드】 SARS-COV-2 infection, oxidative stress, prognostic, assessment, marker, Elderly patient, medium, implication,