Abstract
We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection.
Keywords: Australia; COVID-19; K18-hACE2 mice; Omicron BA.1; SARS-CoV-2; SARS-CoV-2 variants; ancestral; challenge; coronavirus disease; cross-protection; immunogenicity; mice; neutralizing antibodies; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccine-preventable diseases; viruses; zoonoses.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, SARS-CoV-2, immunogenicity, cross-protection, Neutralizing antibodies, Australia, SARS-CoV-2 variants, mice, challenge, K18-hACE2 mice, vaccine-preventable diseases, Omicron BA.1, zoonoses., ancestral, 【초록키워드】 zoonoses, neutralizing antibody, coronavirus, antibody, SARS-COV-2 infection, Infection, Delta, omicron, cross-reactivity, Neutralizing, homologous, Strains, K18-hACE2, acute respiratory syndrome, remained, elicited, 【제목키워드】 Delta, omicron,